Wittgenstein’s Mistress (1988) is Markson’s most critically acclaimed and well-known novel. Taking the style of Springer’s Progress even further, this novel is made of the one or two sentence paragraph thoughts of Kate (whose name also appears later in Reader’s Block), a painter who is, or believes herself to be, the last woman (or man, or animal) on earth. Amongst recollections of her travels (in search of any other people) and her life in a beach house, Kate struggles with the concept of language and how it can adequately represent our thoughts. The novel is brimming with references to art historical figures (more about the artists themselves, than their work), Greek drama, philosophers, writers, and the connections between (some real, some made up by the narrator), as Kate recalls things she has read or learned, sometimes inaccurately (though she does not always realize this). Throughout, an element of despair and loneliness pervades the text. Wittgenstein’s Mistress is a novel unlike any other, vast in its erudition and touching in its sadness.
(Source: https://madinkbeard.com/archives/david-markson-an-introduction)